An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. (16th November 2017)

• Record Type: Journal Article
• Authors: Lourenço, Andre P.; Leite‐Moreira, Adelino F.; Balligand, Jean‐Luc; Bauersachs, Johann; Dawson, Dana; de Boer, Rudolf A.; de Windt, Leon J.; Falcão‐Pires, Inês; Fontes‐Carvalho, Ricardo; Franz, Stefan; Giacca, Mauro; Hilfiker‐Kleiner, Denise; Hirsch, Emilio; Maack, Christoph; Mayr, Manuel; Pieske, Burkert; Thum, Thomas; Tocchetti, Carlo G.; Brutsaert, Dirk L.; Heymans, Stephane
• Is Part Of: European journal of heart failure. Volume 20:Number 2(2018)
• Page Start: 216
• Page End: 227
• Publication Date: 2017-11-16
• Subjects: Heart failure with preserved ejection fraction -- Animal models -- Experimental evaluation -- Molecular biology -- Myocardial function; Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1002/ejhf.1059
• Languages: English
• ISSNs: 1388-9842

Abstract

Abstract : As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long‐term clinical manifestations. We will revise recent advances in animal model development, experimental set‐ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher‐order inter‐organ and inter‐cell communication to achieve a full systems biology perspective of HFpEF.