Possible autoantibody-negative limbic encephalitis after anterior temporal lobectomy for hippocampal sclerosis. (4th May 2018)

• Record Type: Journal Article
• Authors: Casciato, Sara; D'Aniello, Alfredo; Mascia, Addolorata; Quarato, Pier Paolo; De Risi, Marco; Grammaldo, Liliana G.; Esposito, Vincenzo; Zoccarato, Marco; Di Gennaro, Giancarlo
• Is Part Of: International journal of neuroscience. Volume 128:Number 5(2018)
• Page Start: 464
• Page End: 466
• Publication Date: 2018-05-04
• Subjects: Temporal lobe epilepsy -- limbic encephalitis -- memory -- anterior temporal lobectomy -- global amnesia; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2017.1394852
• Languages: English
• ISSNs: 0020-7454

Abstract

ABSTRACT: Purpose: Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. Materials and methods: We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and neuroimaging findings of a damage involving the contralateral mesial temporal lobe structures. Results: A diagnosis of a possible autoimmune encephalitis was made. Conclusions: Due to its peculiarities (compared with other cases of bilateral temporal lesions, the damage occurred on two distinct occasions), this case might contribute to shed light on the issue of the possible contralateral reorganization of memory processes subserved by the mesial temporal lobe structures chronically involved in epileptogenesis.