Cellular quiescence: How TGFβ protects cancer cells from chemotherapy. (4th March 2018)

• Record Type: Journal Article
• Authors: Brown, Jessie A; Schober, Markus
• Is Part Of: Molecular & cellular oncology. Volume 5:Number 2(2018)
• Publication Date: 2018-03-04
• Subjects: cell cycle -- chemotherapy -- cancer stem cells -- quiescence -- resistance -- squamous cell carcinoma -- skin -- TGFβ -- tumor heterogeneity -- tumor propagating cells; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2017.1413495
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFβ signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFβ/Smad signaling can't enter quiescence and subsequently die from chemotherapy.