Syntheses, crystal structures and antibacterial activities of two new Mn(II) complexes based on triaryltriazoles. Issue 1 (2nd January 2018) - Zhang, Shi-Pei
Abstract: Two new Mn(II) complexes, trans -[Mn(L1-L2)2 (NCS)2 ] (1 –2 ) with triaryltriazole (1, L1 = 3-( p -bromophenyl)-4-phenyl-5-(2-pyridyl)-1, 2, 4-triazole;2, L2 = 3, 4-bis( p -methylphenyl)-5-(2-pyridyl)-1, 2, 4-triazole), have been synthesized and structurally characterized by elemental analysis, FT-IR, ESI-MS, and single-crystal X-ray crystallography. Crystallographic studies revealed that both1 and2 contain a distorted octahedral [MnN6 ] core with two trans -disposed NCS − ions. The L1 ligand, 1 and2, together with four known homologous Mn(II) complexes, trans -[Mn(L3-L6)2 (NCS)2 ] (3 –6 ) (3, L3 = 3-( p -methoxyphenyl)-4-( p -chlorophenyl)-5-(2-pyridyl)-1, 2, 4-triazole;4, L4 = 3-( p -methoxyphenyl)-4-( p -bromophenyl)-5-(2-pyridyl)-1, 2, 4-triazole;5, L5 = 3-( p -chlorophenyl)-4-( p -methylphenyl)-5-(2-pyridyl)-1, 2, 4-triazole;6, L6 = 3, 5-bis(2-pyridyl)-4-( p -methylphenyl)-1, 2, 4-triazole), were tested in vitro for their antibacterial activities against two Gram-positive bacterial strains and two Gram-negative bacterial strains by the MTT method. The results indicate that1 exhibited better activity than Penicillin and Kanamycin against Pseudomonas aeruginosa and also better than its free L1 ligand. Abstract :