Synthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexes. Issue 2 (17th January 2018)

• Record Type: Journal Article
• Authors: Solmaz, Ummuhan; Gumus, Ilkay; Binzet, Gun; Celik, Omer; Balci, Gulten Kavak; Dogen, Aylin; Arslan, Hakan
• Is Part Of: Journal of coordination chemistry. Volume 71:Issue 2(2018)
• Page Start: 200
• Page End: 218
• Publication Date: 2018-01-17
• Subjects: Benzoyl thiourea -- platinum complex -- antimicrobial activity -- intermolecular interaction -- crystal structure analysis; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2018.1427233
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: N, N -Di- R - N ′-(4-chlorobenzoyl)thiourea (Di- R : diethyl, di- n -propyl, di- n -butyl and diphenyl) ligands (HL 1–4 ) and their Pt(II) complexes ( cis -[Pt(L 1–4 -S, O)2 ]) have been synthesized and structurally characterized by elemental analyses, FT-IR and NMR spectroscopy. HL 2 ligand and cis -[Pt(L 4 -S, O)2 ] metal complex have been also characterized by a single-crystal X-ray diffraction study. HL 2, C14 H19 ClN2 OS, crystallizes in the monoclinic space group P21 /n (no. 14), with Z = 4, and unit cell parameters, a = 11.1405(16) Å, b = 9.7015(12) Å, c = 14.790(2) Å, β = 106.547(7)°. The cis -[Pt(L 4 -S, O)2 ], C40 H28 Cl2 N4 O2 PtS2 : triclinic, space group P -1 (no. 2), a = 8.9919(3) Å, b = 14.7159(6) Å, c = 15.7954(6) Å, α = 113.9317(18)°, β = 97.4490(18)°, and γ = 105.0492(16)°. Single crystal analysis of complex, cis -[Pt(L 1–4 -S, O)2 ], revealed that a square planar coordination geometry is formed around the platinum atom by two sulfur and two oxygen atoms of the related ligands, which are in a cis configuration. In addition, the thiourea derivative ligands and their complexes were evaluated for both their in-vitro antibacterial and antifungal activity. The results have been reported, explained, and compared with fluconazole and ampicillin, used as reference drugs. Abstract :