Concise and efficient synthesis of eliglustat. Issue 5 (4th March 2018)
- Record Type:
- Journal Article
- Title:
- Concise and efficient synthesis of eliglustat. Issue 5 (4th March 2018)
- Main Title:
- Concise and efficient synthesis of eliglustat
- Authors:
- Liu, Xiaoyu
Li, Xiaoyu
Yang, Hongguang
Shi, Xiang
Yang, Feilong
Jiao, Xiaozhen
Xie, Ping - Abstract:
- ABSTRACT: Eliglustat, a ceramide glucosyltransferase inhibitor, was synthesized in six steps with 28.4% overall yield. The key features include the use of a diastereoselective aldol reaction to construct two contiguous stereocenters and a selective sulfonylation of a 1, 3-diol catalyzed by dibutyltin oxide. GRAPHICAL ABSTRACT:
- Is Part Of:
- Synthetic communications. Volume 48:Issue 5(2018)
- Journal:
- Synthetic communications
- Issue:
- Volume 48:Issue 5(2018)
- Issue Display:
- Volume 48, Issue 5 (2018)
- Year:
- 2018
- Volume:
- 48
- Issue:
- 5
- Issue Sort Value:
- 2018-0048-0005-0000
- Page Start:
- 594
- Page End:
- 600
- Publication Date:
- 2018-03-04
- Subjects:
- Aldol reaction -- eliglustat -- selective sulfonylation -- stereogenic centers
Organic compounds -- Synthesis -- Periodicals
Chemistry, Organic
Synthesis
547.205 - Journal URLs:
- http://www.tandfonline.com/toc/lsyc20/current ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/00397911.2017.1416636 ↗
- Languages:
- English
- ISSNs:
- 0039-7911
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8586.830000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 5871.xml