It's fun to transcribe with Fun30: A model for nucleosome dynamics during RNA polymerase II-mediated elongation. Issue 2 (15th March 2018)

• Record Type: Journal Article
• Authors: Lee, Junwoo; Choi, Eun Shik; Lee, Daeyoup
• Is Part Of: Transcription. Volume 9:Issue 2(2018)
• Page Start: 108
• Page End: 116
• Publication Date: 2018-03-15
• Subjects: chromatin remodeler -- Fun30 -- histone chaperone FACT -- nucleosome barrier -- nucleosome disassembly -- RNAPII elongation; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2017.1356434
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: The ability of elongating RNA polymerase II (RNAPII) to regulate the nucleosome barrier is poorly understood because we do not know enough about the involved factors and we lack a conceptual framework to model this process. Our group recently identified the conserved Fun30/SMARCAD1 family chromatin-remodeling factor, Fun30 Fft3, as being critical for relieving the nucleosome barrier during RNAPII-mediated elongation, and proposed a model illustrating how Fun30 Fft3 may contribute to nucleosome disassembly during RNAPII-mediated elongation. Here, we present a model that describes nucleosome dynamics during RNAPII-mediated elongation in mathematical terms and addresses the involvement of Fun30 Fft3 in this process.