P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II. Issue 2 (15th March 2018)

• Record Type: Journal Article
• Authors: Li, You; Liu, Min; Chen, Lin-Feng; Chen, Ruichuan
• Is Part Of: Transcription. Volume 9:Issue 2(2018)
• Page Start: 88
• Page End: 94
• Publication Date: 2018-03-15
• Subjects: 7SK snRNP -- Brd4 -- KAP1 -- promoter-proximal pausing -- P-TEFb -- RNA Pol II -- SEC -- transcription elongation; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2017.1281864
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.