Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism. Issue 10 (29th January 2018)

• Record Type: Journal Article
• Authors: Boersch, M.; Rudrawar, S.; Grant, G.; Zunk, M.
• Is Part Of: RSC advances. Volume 8:Issue 10(2018)
• Page Start: 5099
• Page End: 5105
• Publication Date: 2018-01-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra12950e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Menaquinone is essential in electron transport and ATP generation in all Gram-positive, and anaerobically respiring Gram-negative bacteria. Inhibition of menaquinone production at different steps of the biosynthesis pathway has shown promising novel antibacterial action. Abstract : Menaquinone is essential in electron transport and ATP generation in all Gram-positive, and anaerobically respiring Gram-negative bacteria. By inhibiting menaquinone production in target organisms, bactericidal action can be achieved irrespective of the organisms' growth phase. This pathway is absent in human cells, as menaquinone is obtained only through the diet. This paper provides a succinct review of major advancements, where present, at all enzymatic steps of the biosynthetic pathway of menaquinone. Structure–activity relationships are evaluated, as well as results translating these relationships to growth inhibition studies.