Monte Carlo modelling of live-timed anticoincidence (LTAC) counting for Cu-64. (April 2018)

• Record Type: Journal Article
• Authors: Bergeron, Denis E.; Fitzgerald, Ryan
• Is Part Of: Applied radiation and isotopes. Volume 134(2018:Apr.)
• Page Start: 280
• Page End: 285
• Publication Date: 2018-04
• Subjects: Beta-gamma coincidence method -- Anticoincidence -- Liquid scintillation -- Monte Carlo simulations; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2017.09.032
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: The radionuclide copper-64 is a promising candidate for nuclear medicine, but its complex decay creates challenges in the primary standardization of its activity. Monte Carlo simulations of live-timed anticoincidence (LTAC) counting of 64 Cu were used to calculate corrections to extrapolation intercepts, resulting in improved activity determinations. A small correction (−0.33%) to the linear extrapolation of LTAC data acquired with a γ-gate over the 1346 keV gamma peak was determined. We discuss the physical origin of the correction. We also use experimental data to demonstrate a Monte Carlo scaling that allows for inclusion of data acquired with a γ-gate set over the annihilation photon peak(s). Highlights: Monte Carlo simulations of 64 Cu LTAC found a 0.33% correction to the linear extrapolation. The intercept of a linear extrapolation is insensitive to some model deficiencies. A Monte Carlo scaling approach allows the use of data acquired with a γ-gate set over the annihilation photon peak(s).