Notching a New Pathway in Vascular Flow Sensing. Issue 3 (March 2018)

• Record Type: Journal Article
• Authors: Lagendijk, Anne K.; Yap, Alpha S.; Hogan, Benjamin M.
• Is Part Of: Trends in cell biology. Volume 28:Issue 3(2018)
• Page Start: 173
• Page End: 175
• Publication Date: 2018-03
• Subjects: Notch -- VE-cadherin -- vascular -- endothelial -- endothelial barrier; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2017.12.003
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Vascular barrier function is controlled at cell–cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms controlling the endothelial barrier.