Portrait of Candida Species Biofilm Regulatory Network Genes. Issue 1 (January 2017) - Araújo, Daniela
Abstract : Most cases of candidiasis have been attributed to Candida albicans, but Candida glabrata, Candida parapsilosis and Candida tropicalis, designated as non- C. albicans Candida (NCAC), have been identified as frequent human pathogens. Moreover, Candida biofilms are an escalating clinical problem associated with significant rates of mortality. Biofilms have distinct developmental phases, including adhesion/colonisation, maturation and dispersal, controlled by complex regulatory networks. This review discusses recent advances regarding Candida species biofilm regulatory network genes, which are key components for candidiasis. Trends: Candida albicans is the main cause of candidiasis, however, non- C. albicans Candida species are now frequently identified as potential human pathogens. Biofilm formation is a potent virulence factor for a number of Candida species, as it confers significant resistance to traditional antifungal therapy. There are common genetic requirements for biofilm formation; however, much work is needed to complete the picture of biofilm regulatory network genes.