Everolimus‐associated perianal ulcers in an eight‐month‐old heart transplant recipient. (24th October 2017)

• Record Type: Journal Article
• Authors: Spehl, Marco S.; Fleck, Thilo; Schauer, Franziska; Meiss, Frank; Stiller, Brigitte
• Is Part Of: Pediatric transplantation. Volume 22:Number 1(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-10-24
• Subjects: everolimus -- gastrointestinal -- infant -- mammalian target of rapamycin -- pediatric heart transplant -- ulceration; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.13072
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: mTOR inhibitors have a wide spectrum of therapeutic applications in adults and children. Little is known, however, about serious adverse effects in children undergoing mTOR inhibitor therapy. Oral ulcers are common and sometimes severe, but no other gastrointestinal involvement has been reported so far. Here we present a case of everolimus‐associated perianal ulcers in an eight‐month‐old infant, 3 months after heart transplantation, which necessitated the drug's discontinuation. In a thorough series of diagnostic tests, we identified no other cause for the progressive perianal ulceration. The recognition and appropriate management of mTOR inhibitors' adverse effects in pediatric patients are essential and remain challenging.