Combined Fish Oil and High Oleic Sunflower Oil Supplements Neutralize their Individual Effects on the Lipid Profile of Healthy Men. Issue 9 (26th July 2013)

• Record Type: Journal Article
• Authors: Hlais, Sani; El‐Bistami, Dunia; El Rahi, Berna; Mattar, Mélanie A.; Obeid, Omar A.
• Is Part Of: Lipids. Volume 48:Issue 9(2013)
• Page Start: 853
• Page End: 861
• Publication Date: 2013-07-26
• Subjects: Fish oil -- Oleic acid -- Triglycerides -- TC -- LDL‐C -- Glucose -- Insulin -- Blood pressure; Lipids -- Periodicals; Lipids -- Periodicals; Lipiden; Lipides -- Périodiques; 547.77
• DOI: 10.1007/s11745-013-3819-x
• Languages: English
• ISSNs: 0024-4201

Abstract

Abstract: Both n‐3 and n‐9 fatty acids share a common metabolic pathway and can potentially and individually improve cardiovascular disease risk factors. Dietary n‐6 is known to weaken the efficacy of n‐3 fatty acids due to competition for the same enzymes. Still unclear is whether a similar competition exists between n‐3 and n‐9 fatty acids. Thus, a 12‐week intervention study was conducted to investigate the effect of different combinations of fish oil and high‐oleic sunflower oil (OSO) on healthy subjects. Included were five groups (98 subjects): three groups received a fixed amount of n‐9 (8 g/day) with varying amounts of n‐3 (1, 2 or 4 g/day), one group was given n‐3 fatty acids only (2 g/day) and another was given n‐9 only (8 g/day). We found that fish oil supplement (2 g/day) was able to decrease TAG by about 13 %, this effect was diminished with the co‐ingestion of n‐9 (OSO). Intake of OSO (8 g/day) reduced both total and LDL cholesterol by about 10 %, this effect was reduced by the addition of fish oil. Both fish oil and OSO failed to have any significant effect on both glycemic and blood pressure parameters. In conclusion; the impact of oleic acid (n‐9) on total and LDL cholesterol was altered by the addition fish oil (n‐3). These effects may have been the result of enzymatic competition between the two types of fatty acids.