Long noncoding RNAs in T lymphocytes. Issue 1 (4th November 2015)

• Record Type: Journal Article
• Authors: Aune, Thomas M.; Crooke, Phillip S.; Spurlock, Charles F.
• Is Part Of: Journal of leukocyte biology. Volume 99:Issue 1(2016)
• Page Start: 31
• Page End: 44
• Publication Date: 2015-11-04
• Subjects: epigenetics -- lncRNA -- adaptive immunity; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.1RI0815-389R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on the expression patterns and functions of long noncoding RNAs in the T cell compartment of the adaptive immune system. Abstract : Long noncoding RNAs are recently discovered regulatory RNA molecules that do not code for proteins but influence a vast array of biologic processes. In vertebrates, the number of long noncoding RNA genes is thought to greatly exceed the number of protein‐coding genes. It is also thought that long noncoding RNAs drive the biologic complexity observed in vertebrates compared with that in invertebrates. Evidence of this complexity has been found in the T‐lymphocyte compartment of the adaptive immune system. In the present review, we describe our current level of understanding of the expression of specific long or large intergenic or intervening long noncoding RNAs during T‐lymphocyte development in the thymus and differentiation in the periphery and highlight the mechanisms of action that specific long noncoding RNAs employ to regulate T‐lymphocyte function, both in vitro and in vivo.