Tert‐Butyl Nitrite Mediated Expeditious Methylsulfoxidation of Tetrazole‐amines with DMSO: Metal‐free Synthesis of Antifungal Active Methylsulfinyl‐1H‐tetrazole Derivatives. Issue 3 (12th December 2017)

• Record Type: Journal Article
• Authors: Dai, Peng; Luo, Kai; Yu, Xiang; Yang, Wen‐Chao; Wu, Lei; Zhang, Wei‐Hua
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 3(2018)
• Page Start: 468
• Page End: 473
• Publication Date: 2017-12-12
• Subjects: Methylsulfoxidation -- Tetrazole-amines -- tert-butyl Nitrite -- Methylsulfinyl-1H-tetrazole -- Antifungal Activity; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201701364
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A tert ‐butyl nitrite mediated methyl‐sulfoxidation of tetrazole‐amines in neat DMSO or methyl‐sulfinyl derivatives is revealed for the first time. The reaction exhibits good group tolerance, as well as highly selectivity to sulfinyl substitutions. This new protocol provides an expeditious and operationally simple procedure for C−S(O) bond construction. Preliminary bioactivity evaluation on selected products shows promising antifungal activities. Abstract :