Contribution of spinal cord biopsy to diagnosis of aquaporin-4 antibody positive neuromyelitis optica spectrum disorder. (June 2014)

• Record Type: Journal Article
• Authors: Ringelstein, M; Metz, I; Ruprecht, K; Koch, A; Rappold, J; Ingwersen, J; Mathys, C; Jarius, S; Brück, W; Hartung, H-P; Paul, F; Aktas, O
• Other Names: Langel Stefan non-byline-author.; Oy Ulrich Hofstadt-van non-byline-author.; Reuss Reinhard non-byline-author.; Wilke Christian non-byline-author.; Münch Christoph non-byline-author.; Hellwig Kerstin non-byline-author.; Kleiter Ingo non-byline-author.; Niehaus Sabine non-byline-author.; Melms Arthur non-byline-author.; Linker Ralf non-byline-author.; Mayer Christoph non-byline-author.; Guthke Kersten non-byline-author.; Pellkofer Hannah non-byline-author.; Hoffmann Frank non-byline-author.; Zentner Christian non-byline-author.; Stangel Martin non-byline-author.; Trebst Corinna non-byline-author.; Wildemann Brigitte non-byline-author.; Geis Christian non-byline-author.; Ettrich Barbara non-byline-author.; Bergh Florian Then non-byline-author.; Wandinger Klaus-Peter non-byline-author.; Berthele Achim non-byline-author.; Hemmer Bernhard non-byline-author.; Kümpfel Tania non-byline-author.; Marziniak Martin non-byline-author.; Böttcher Tobias non-byline-author.; Rommer Paulus S non-byline-author.; Neuhaus Oliver non-byline-author.; Sieb Jörn-Peter non-byline-author.; Veauthier Christian non-byline-author.; Faiss Jürgen non-byline-author.; Kern Peter non-byline-author.; Ziemann Ulf non-byline-author.; Tumani Hayrettin non-byline-author.; Lauda Florian non-byline-author.; Brettschneider Johannes non-byline-author.; Liebetrau Martin non-byline-author.; Kleinschnitz Christoph non-byline-author.; Schippling Sven non-byline-author.;
• Is Part Of: Multiple sclerosis. Volume 20:Number 7(2014)
• Page Start: 882
• Page End: 888
• Publication Date: 2014-06
• Subjects: Spinal cord tumor -- longitudinally extensive spinal cord lesion -- spinal biopsy -- longitudinally extensive transverse myelitis -- neuromyelitis optica -- aquaporin-4 antibody; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458513510981
• Languages: English
• ISSNs: 1352-4585

Abstract

Longitudinally extensive transverse myelitis is characteristic but not pathognomonic for neuromyelitis optica spectrum disorders (NMOSDs) and may mimic local tumors. In this retrospective study based on a cohort of 175 NMOSD patients we identified seven patients who initially presented with a longitudinally extensive spinal cord lesion and underwent spinal cord biopsy due to magnetic resonance imaging (MRI)-suspected malignancies. Remarkably, routine neuropathology was inconclusive and did not guide the diagnostic process to anti-aquaporin-4 (AQP4)-seropositive NMOSD. Serious postoperative complications occurred in 5/7 patients and persisted during follow-up in 2/7 patients (29%). Considering these sequelae, AQP4-antibody testing should be mandatory in patients with inconclusive longitudinally extensive spinal cord lesions prior to biopsy.