A molecular zipping/unzipping nano-vehicles sensitive to tumor extracellular pH. (July 2014)

• Record Type: Journal Article
• Authors: Lee, Jung Ok; Lee, Min Ji; Kim, Dongin; Lee, Eun Seong
• Is Part Of: Journal of bioactive and compatible polymers. Volume 29:Number 4(2014:Jul.)
• Page Start: 368
• Page End: 381
• Publication Date: 2014-07
• Subjects: pH-responsive nano-vehicles -- β-cyclodextrin -- tumor extracellular pH -- tumor targeting -- zipping/unzipping -- host–guest interaction; Biomedical materials -- Periodicals; Polymers in medicine -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0883911514533866
• Languages: English
• ISSNs: 0883-9115

Abstract

A new class of pH- responsive multivalent host –guest interactions to manipulate polypeptide-based nano-vehicles was developed. Poly(l -lysine) (poly(Lys)) grafted with β-cyclodextrin and 2, 3-dimethylmaleic acid was coupled with oleic acid. This new polymer was utilized to fabricate pH-responsive nano-vehicles for antitumor drug doxorubicin delivery. The host–guest (zipping) interaction between β-cyclodextrin and 2, 3-dimethylmaleic acid moieties and the hydrophobic interaction between the oleic acid molecules contributed to form self-assembled nano-vehicles. 2, 3-Dimethylmaleic acid moieties were highly degradable at a slightly acidic pH (~pH 6.8). These nano-vehicles increased the release of the encapsulated doxorubicin content (by the unzipping interaction between β-cyclodextrin and degraded 2, 3-dimethylmaleic acid moieties) when the pH of the solution decreased to 6.8. This event caused a significant increase in the efficiency of cellular doxorubicin uptake and in vitro tumor inhibition.