Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate. (May 2014)

• Record Type: Journal Article
• Authors: Taguchi, Tetsushi; Okada, Masahiro; Kogai, Yasumichi; Masuda, Miwa; Shimomura, Yumi; Inoue, Motoki; Ito, Temmei; Hamahata, Takashi; Funatogawa, Keiji; Kirikae, Teruo; Furuzono, Tsutomu
• Is Part Of: Journal of bioactive and compatible polymers. Volume 29:Number 3(2014:May)
• Page Start: 284
• Page End: 297
• Publication Date: 2014-05
• Subjects: Catheter -- infection -- adhesive -- human serum albumin -- organic acid; Biomedical materials -- Periodicals; Polymers in medicine -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0883911514528409
• Languages: English
• ISSNs: 0883-9115

Abstract

A new material was prepared to reduce catheter infection composed of a flocked silicone sheet (AmTiO2 NP-F) with TiO2 nanoparticle–immobilized poly(ethylene terephthalate) fibers modified with surface amino groups. This system was used in conjunction with a tissue adhesive composed of disuccinimidyl tartrate and human serum albumin. At a fixed disuccinimidyl tartrate content of 0.2 mmol in human serum albumin solution, AmTiO2 NP-F bonded well with collagen-based casing (a model material for skin), with bond strength increasing to a maximum of 38 w/v% human serum albumin. The adhesive bonded AmTiO2 NP-F to subcutaneous tissue in mice, and infiltration of the tissue into the AmTiO2 NP-F further increased the bond strength for long-term insertions. The material was degraded within 7 days of implantation, and tissue reaction was mild, while infection was completely prevented. These results indicate that the combined use of AmTiO2 NP-F and disuccinimidyl tartrate-A for implanted catheters can significantly alleviate the associated risk of infection.