Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy. (June 2014)

• Record Type: Journal Article
• Authors: Kim, Jae Heon; Lee, Sang Wook; Kim, Jae Ho; Yang, Hee Jo; Doo, Seung Whan; Yoon, Jong Hyun; Kim, Doo Sang; Yang, Won Jae; Lee, Kwang Woo; Kim, Jun Mo; Lee, Changho; Kwon, Soon-Sun
• Is Part Of: Journal of international medical research. Volume 42:Number 3(2014:Jun.)
• Page Start: 821
• Page End: 827
• Publication Date: 2014-06
• Subjects: Prostate-specific antigen -- prostate-specific antigen density -- body mass index; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060513518038
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To determine the association between body mass index (BMI), serum prostate-specific antigen (PSA) level and PSA density (PSAD) in patients with an elevated serum PSA level but a negative prostate biopsy. Methods: This retrospective study enrolled men with a negative prostate biopsy but a serum PSA level of 3.0–10 ng/ml. All men underwent anthropometric measurements, serum PSA determination and transrectal ultrasound examination. BMI was grouped according to the Asia-Pacific obesity criteria: nonobese (<25 kg/m 2 ) versus obese (≥25 kg/m 2 ). Partial correlation and linear regression models between PSA, PSAD and BMI were conducted after adjusting for age. Results: A total of 907 men were enrolled in this study. On multivariate analyses, PSA showed no significant correlation with age or BMI, whereas PSAD had a negative correlation with age and BMI. Similar results were obtained when patients were categorized as having low (3.0 < PSA ≤ 6.5 ng/ml) or high PSA (6.5 < PSA ≤ 10.0 ng/ml) levels. Conclusion: PSAD, but not PSA, demonstrated a significant negative correlation with BMI. This indicates that a new strategy including PSAD rather than simple PSA levels should be adopted in the study of obesity-adjusted PSA cut-offs.