Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study. (17th February 2018)

• Record Type: Journal Article
• Authors: Peura, Sari; Fall, Tove; Almqvist, Catarina; Andolf, Ellika; Hedman, Anna; Pershagen, Göran; Helmersson-Karlqvist, Johanna; Larsson, Anders
• Is Part Of: Scandinavian journal of clinical & laboratory investigation. Volume 78:Number 1/2(2018)
• Page Start: 120
• Page End: 124
• Publication Date: 2018-02-17
• Subjects: Calprotectin -- turbidimetric immunoassay -- normal values -- inflammatory bowel disease -- abdominal pain; Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Physiology, Experimental -- Periodicals; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 616.0072
• DOI: 10.1080/00365513.2017.1420216
• Languages: English
• ISSNs: 0036-5513

Abstract

Abstract: Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is that opposite to previously used enzyme-linked immunosorbent assay (ELISA) method, it enables measuring single samples, and thus, shortens the analysis time significantly. There were 72 samples (41.7% female) collected neonatally, 63 samples (34.9% female) at 6 months, 60 samples (40.0% female) at 12 months and 51 samples (43.1% female) at 24 months. The upper limits for normal values were 233, 615, 136 and 57 µg mg −1 for infants aged 0, 6, 12 and 24 months, respectively.