Reduction of FENO by tap water and carbonated water mouthwashes: magnitude and time course. (17th February 2018)

• Record Type: Journal Article
• Authors: Lassmann-Klee, Paul Guenther; Lindholm, Tuula; Metsälä, Markus; Halonen, Lauri; Sovijärvi, Anssi Raimo Antero; Piirilä, Päivi
• Is Part Of: Scandinavian journal of clinical & laboratory investigation. Volume 78:Number 1/2(2018)
• Page Start: 153
• Page End: 156
• Publication Date: 2018-02-17
• Subjects: Fractional exhaled nitric oxide (FENO) -- carbonated water -- mouthwash -- tap water -- asthma -- inflammation -- laboratory standardization; Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Physiology, Experimental -- Periodicals; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 616.0072
• DOI: 10.1080/00365513.2017.1419574
• Languages: English
• ISSNs: 0036-5513

Abstract

Abstract: Fractional exhaled nitric oxide ( F ENO ) assesses eosinophilic inflammation of the airways, but F ENO values are also influenced by oral nitric oxide (NO). The aim of this pilot study was to measure F ENO and compare the effect of two different mouthwashes on F ENO and analyse the duration of the effect. F ENO was measured in 12 randomized volunteers (healthy or asthmatic subjects) with a NIOX VERO® analyser at an expiratory flow rate of 50 mL/s. After a baseline measurement, a mouthwash was performed either with tap water or carbonated water and was measured during 20 min in 2 min intervals. The procedure was repeated with the other mouthwash. We found that both mouthwashes reduced F ENO immediately at the beginning compared to the baseline ( p < .001). The carbonated water mouthwash effect lasted 12 min ( p ranging from <0.001 to <0.05). The tap water mouthwash reduced F ENO statistically significantly only for 2 min compared with the baseline. We conclude that a single carbonated water mouthwash can significantly reduce the oropharyngeal NO contribution during a 12 min time interval.