Immunosuppressive roles of natural killer T (NKT) cells in the skin. Issue 1 (5th May 2014)

• Record Type: Journal Article
• Authors: McKee, Sara J.; Mattarollo, Stephen R.; Leggatt, Graham R.
• Is Part Of: Journal of leukocyte biology. Volume 96:Issue 1(2014)
• Page Start: 49
• Page End: 54
• Publication Date: 2014-05-05
• Subjects: nonmelanoma skin cancer -- ultraviolet radiation -- transplantation -- glycolipids; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.4RU0114-001R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review of how NKT cells suppress immune responses in the skin, with implications for the design of immunotherapies to treat various skin pathologies. Abstract : The skin is a complex immunological niche providing immunity to invading pathogens while simultaneously maintaining tolerance to innocuous environmental antigens. Consistent with this complex response, the skin is resident to both immunosuppressive and effector cell populations whose activities are tightly regulated. While NKT cells can activate immune responses in the skin, this review will highlight studies on UV‐induced photodamage, models of NMSCs, transplantation and allergic inflammation where NKT cells appear to have an immunosuppressive role in the skin.