Choriocarcinoma-like tumor in a potbellied pig (Sus scrofa). (January 2014)

• Record Type: Journal Article
• Authors: Hirata, Akihiro; Miyazaki, Aya; Sakai, Hiroki; Imada, Nanae; Kitani, Ryohei; Nikami, Hideki; Yanai, Tokuma
• Is Part Of: Journal of veterinary diagnostic investigation. Volume 26:Number 1(2014:Jan.)
• Page Start: 163
• Page End: 166
• Publication Date: 2014-01
• Subjects: Choriocarcinoma -- potbellied pigs -- trophoblast -- uterus; Veterinary medicine -- Diagnosis -- Periodicals; 636.0896075
• DOI: 10.1177/1040638713515481
• Languages: English
• ISSNs: 1040-6387

Abstract

A uterine tumor, with histological and immunohistochemical features consistent with those of human choriocarcinoma, was identified in a 10-year-old unmated female pot-bellied pig ( Sus scrofa ). The tumor showed biphasic proliferation of cytotrophoblast-like cells and syncytiotrophoblast-like cells. Immunohistochemically, the syncytiotrophoblast-like cells were positive for human chorionic gonadotropin, and both types of cells were positive for cytokeratin and negative for vimentin, octamer-binding transcription factor 4, and α-fetoprotein. Because syncytiotrophoblasts are absent in the normal porcine placenta, the tumor was diagnosed as a choriocarcinoma-like tumor.