Tailoring Cellular Uptake of Gold Nanoparticles Via the Hydrophilic‐to‐Hydrophobic Ratio of their (Co)polymer Coating. (13th May 2015)

• Record Type: Journal Article
• Authors: Zhang, Zhiyue; Van Steendam, Katleen; Maji, Samarendra; Balcaen, Lieve; Anoshkina, Yulia; Zhang, Qilu; Vanluchene, Glenn; De Rycke, Riet; Van Haecke, Frank; Deforce, Dieter; Hoogenboom, Richard; De Geest, Bruno G.
• Is Part Of: Advanced functional materials. Volume 25:Number 22(2015)
• Page Start: 3433
• Page End: 3439
• Publication Date: 2015-05-13
• Subjects: dendritic cells -- flow cytometry -- gold nanoparticles -- polymers -- protein corona; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201500904
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : It is demonstrated how cellular uptake and protein corona of (co)polymer‐coated gold nanoparticles can be altered by the hydrophilic‐to‐hydrophobic comonomer ratio. A novel, label‐free flow cytometry strategy is developed to investigate particle uptake. These findings offer insight in the design and analysis of hybrid nanomaterials for interfacing with biological systems. Abstract : Cellular uptake of gold nanoparticles depends on the hydrophilic‐to‐hydrophobic balance of the (co)polymer coating as shown by a novel flow cytometry strategy.