The future of murine sepsis and trauma research models. Issue 6 (1st June 2015)

• Record Type: Journal Article
• Authors: Efron, Philip A.; Mohr, Alicia M.; Moore, Frederick A.; Moldawer, Lyle L.
• Is Part Of: Journal of leukocyte biology. Volume 98:Issue 6(2015)
• Page Start: 945
• Page End: 952
• Publication Date: 2015-06-01
• Subjects: translation -- immunity; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.5MR0315-127R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on researchers' need to improve or adapt well‐established models to increase their clinical relevancy. Abstract : Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini‐review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma.