Incidence and predictive factors of depression among patients with HIV infection in Guadeloupe: 1988–2009. (July 2014)

• Record Type: Journal Article
• Authors: Elenga, Narcisse; Georger-Sow, Marie-Thérèse; Messiaen, Thierry; Lamaury, Isabelle; Favre, Isabelle; Nacher, Mathieu; Beaucaire, Gilles
• Is Part Of: International journal of STD & AIDS. Volume 25:Number 8(2014:Aug.)
• Page Start: 559
• Page End: 563
• Publication Date: 2014-07
• Subjects: HIV -- AIDS -- mood disorders -- Guadeloupe -- depression -- incidence -- predictive factors; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462413514954
• Languages: English
• ISSNs: 0956-4624

Abstract

Summary: A retrospective cohort study was conducted to determine the incidence and the predictive factors of depression in a cohort of 2737 HIV/AIDS-infected patients in Guadeloupe followed for a total of 8402 patient-years. The incidence rate of first observed depression was 2.2 per 100 person-years (95% confidence interval [CI], 1.9–2.6). A single failure Cox proportional hazards model showed that the 1997–2000 inclusion period (hazard ratio [HR] = 1.60; 95% CI = 1.10–2.40; p = 0.01), the 2001–2009 inclusion period (HR = 1.50; 95% CI = 1.02–2.40; p = 0.04), the more advanced CDC stage (HR = 2.30; 95% CI = 1.30–3.10; p = 0.000) and the annual frequency of visits > 10 (HR = 2.30; 95% CI = 1.70–3.30; p = 0.000) were associated with an increased risk of depression. Incidence of depression in this HIV cohort was high and the hazard function showed three peaks of depression (2, 7 and 12 years). Physicians should be vigilant to psychological distress throughout life with HIV.