The value of microparticles in detecting acute rejection episodes after liver transplantation. (2nd January 2018)

• Record Type: Journal Article
• Authors: Morgul, Mehmet Haluk; Splith, Katrin; Leonhardt, Christoph; Raschzok, Nathanael; Reutzel-Selke, Anja; Schmuck, Rosa Bianca; Andreou, Andreas; Atanasov, Georgi; Benzing, Christian; Krenzien, Felix; Hau, Hans-Michael; Felgendreff, Philipp; Klunk, Sergej; Pratschke, Johann; Sauer, Igor Maximillian; Schmelzle, Moritz
• Is Part Of: Biomarkers. Volume 23:Number 1(2018)
• Page Start: 25
• Page End: 32
• Publication Date: 2018-01-02
• Subjects: T cell-derived microparticles -- endothelial cell-derived microparticles -- regulatory T cells -- graft monitoring -- non-invasive marker; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2017.1306754
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet. Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR. Materials and Methods: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation. Results: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups. Discussion and Conclusion: MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.