A case of multicentric Castleman's disease in HIV infection with the rare complication of acquired angioedema. (June 2014)

• Record Type: Journal Article
• Authors: Fernando, I; Scott, G
• Is Part Of: International journal of STD & AIDS. Volume 25:Number 7(2014:Jul.)
• Page Start: 523
• Page End: 525
• Publication Date: 2014-06
• Subjects: Multicentric Castleman's disease -- human herpes virus-8 -- HHV-8 -- HIV -- AIDS -- HAART (highly-active anti-retroviral therapy) -- immune restoration inflammatory syndrome -- acquired angioedema; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462413516941
• Languages: English
• ISSNs: 0956-4624

Abstract

Multicentric Castleman's disease (MCD), a polyclonal lymphoproliferative disorder of unknown aetiology, is a well-recognised complication of HIV disease. We present a case of MCD in an HIV-positive patient that is unusual on two counts: our patient's MCD first presented in the context of an immune restoration inflammatory syndrome (IRIS), following the initiation of highly active antiretroviral therapy (HAART). In addition, her MCD was associated with the unusual complication of acquired angioedema (AAE), which resolved following treatment of the MCD. While AAE is frequently found to have an underlying diagnosis of a lymphoproliferative disease, this is the first reported case linking AAE to MCD.