Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Liu, Na; Pan, Xiong‐Fei; Yu, Canqing; Lv, Jun; Guo, Yu; Bian, Zheng; Yang, Ling; Chen, Yiping; Wu, Tangchun; Chen, Zhengming; Pan, An; Li, Liming
• Other Names: Chen Junshi investigator.; Collins Rory investigator.; Peto Richard investigator.; Lancaster Garry investigator.; Yang Xiaoming investigator.; Williams Alex investigator.; Smith Margaret investigator.; Chang Yumei investigator.; Zhao Guoqing investigator.; Wu Lixue investigator.; Hou Can investigator.; Pang Zengchang investigator.; Wang Shaojie investigator.; Zhang Yun investigator.; Zhang Kui investigator.; Liu Silu investigator.; Zhao Zhonghou investigator.; Liu Shumei investigator.; Pang Zhigang investigator.; Feng Weijia investigator.; Wu Shuling investigator.; Yang Liqiu investigator.; Han Huili investigator.; He Hui investigator.; Pan Xianhai investigator.; Wang Shanqing investigator.; Wang Hongmei investigator.; Hao Xinhua investigator.; Chen Chunxing investigator.; Lin Shuxiong investigator.; Hu Xiaoshu investigator.; Zhou Minghao investigator.; Wu Ming investigator.; Wang Yeyuan investigator.; Hu Yihe investigator.; Ma Liangcai investigator.; Zhou Renxian investigator.; Xu Guanqun investigator.; Dong Baiqing investigator.; Chen Naying investigator.; Huang Ying investigator.; Li Mingqiang investigator.; Meng Jinhuai investigator.; Gan Zhigao investigator.; Xu Jiujiu investigator.; Liu Yun investigator.; Wu Xianping investigator.; Gao Yali investigator.; Zhang Ningmei investigator.; Luo Guojin investigator.; Que Xiangsan investigator.; Chen Xiaofang investigator.; Ge Pengfei investigator.; He Jian investigator.; Ren Xiaolan investigator.; Zhang Hui investigator.; Mao Enke investigator.; Li Guanzhong investigator.; Li Zhongxiao investigator.; He Jun investigator.; Liu Guohua investigator.; Zhu Baoyu investigator.; Zhou Gang investigator.; Feng Shixian investigator.; Gao Yulian investigator.; He Tianyou investigator.; Jiang Li investigator.; Qin Jianhua investigator.; Sun Huarong investigator.; Liu Liqun investigator.; Yu Min investigator.; Chen Yaping investigator.; Hu Zhixiang investigator.; Hu Jianjin investigator.; Qian Yijian investigator.; Wu Zhiying investigator.; Chen Lingli investigator.; Liu Wen investigator.; Li Guangchun investigator.; Liu Huilin investigator.; Long Xiangquan investigator.; Xiong Youping investigator.; Tan Zhongwen investigator.; Xie Xuqiu investigator.; Peng Yunfang investigator.;
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 12(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-12
• Subjects: Chinese -- depression -- ischemic heart disease -- prospective cohort study; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.116.004687
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results: Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004–2008) until December 31, 2013. Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview‐Short Form at baseline. Incident IHD cases were identified through linkage to related medical databases, and defined as having International Statistical Classification of Diseases and Related Health Problems 10th Revision codes of I20 to I25. Cox proportional hazards regression models were used to estimate hazard ratios and 95% CIs for the MD‐IHD association with adjustment for sociodemographic variables and established cardiovascular risk factors. During 3 423 542 person‐years of follow‐up, 24 705 incident IHD cases were documented. Higher IHD incidence was observed in participants with MD compared with those without (8.76 versus 7.21 per 1000 person‐years), and the multivariable‐adjusted hazard ratio was 1.32 (95% CI 1.15–1.53). Geographic location modified the association ( P for interaction=0.005), and a positive association was observed in urban residents (hazard ratio 1.72; 95% CI 1.39–2.14) but not rural residents (1.13; 0.93–1.37). Compared with participants without depressive symptoms, the hazard ratio (95% CI) of IHD was 1.13 (1.04–1.23) for those with depressive symptoms only and 1.33 (1.15–1.53) for those with MD. Conclusions: Past year major depression was associated with an increased risk of IHD in Chinese adults, independent of other major cardiovascular risk factors.