ABCB1 gene polymorphisms and violent suicide attempt among survivors. (February 2015)

• Record Type: Journal Article
• Authors: Peñas-Lledó, E.; Guillaume, S.; Delgado, A.; Naranjo, M.E.G.; Jaussent, I.; LLerena, A.; Courtet, P.
• Is Part Of: Journal of psychiatric research. Volume 61(2015:Feb.)
• Page Start: 52
• Page End: 56
• Publication Date: 2015-02
• Subjects: Suicide attempt -- Violent suicide methods -- ABCB1; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2014.12.005
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Introduction: Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for P-gp. Thus, this study examined, for the first time, whether these ABCB1 SNPs were associated with the use of violent means among survivors of a suicide attempt. Material and methods: Suicide attempters (n = 578, 87.4% women; of whom 16.6% committed a violent intent) were genotyped for exonic SNPs in the ABCB1 (C1236T, G2677T/A, C3435T). The relations of the three genotypes and of the TTT haplotype with the use of a violent suicide method were evaluated separately. The impact of confounds on these variables was controlled. Results: A higher frequency ( p = 0.02) of suicide attempters using violent methods was found among those carrying the ABCB1 haplotype (1236TT-2677TT-3435TT). Since gender and number of previous suicide attempts were identified as confounds, the relation was tested in the subset of women who were first-time attempters or second- and more-time attempters. The ABCB1 haplotype increased the risk more than three times in those women attempting a violent suicide for the first time (OR = 3.6; CI95%: 1.08–12.09; p = 0.04). Discussion: The ABCB1 haplotype (1236TT-2677TT-3435TT) was related to the use of a violent suicide attempt method. Genotyping for these three ABCB1 SNPs may be helpful to detect people at risk of first suicide intents using violent methods. Highlights: The T allele in the three most common ABCB1 SNPs was most frequent among individuals who dead by using violent suicide methods. Present result show a higher frequency of suicide attempters using violent methods among ABCB1 haplotype (1236TT-2677TT-3435 TT) carriers. This ABCB1 haplotype increased the risk more than three times among women attempting a violent suicide for the first time.