A copper-catalyzed sulfonylative C–H bond functionalization from sulfur dioxide and aryldiazonium tetrafluoroborates. Issue 3 (18th October 2017)

• Record Type: Journal Article
• Authors: Xia, Hongguang; An, Yuanyuan; Zeng, Xincheng; Wu, Jie
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 3(2018)
• Page Start: 366
• Page End: 370
• Publication Date: 2017-10-18
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00866j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Sulfonylative C–H bond functionalization through a copper-catalyzed three-component reaction of 8-aminoquinoline amides, DABCO·(SO2 )2 and aryldiazonium tetrafluoroborates is developed. Excellent selectivity in the para -position is observed. Abstract : Sulfonylative C–H bond functionalization through a copper-catalyzed three-component reaction of 8-aminoquinoline amides, DABCO·(SO2 )2 and aryldiazonium tetrafluoroborates is developed. Excellent selectivity in the para -position is observed for this copper-catalyzed transformation. This reaction is triggered by a copper-chelated complex via the coordination of the copper catalyst with the substrate and arylsulfonyl radical generated in situ, thus providing 5-sulfonyl-8-aminoquinoline amides in moderate to good yields.