L-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone. Issue 3 (20th October 2017)

• Record Type: Journal Article
• Authors: Xu, Youguo; Zhang, Sheng; Li, Lijun; Wang, Yukang; Zha, Zhenggen; Wang, Zhiyong
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 3(2018)
• Page Start: 376
• Page End: 379
• Publication Date: 2017-10-20
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00796e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A highly enantioselective formal [3 + 3] annulation of 2-enoyl-pyridine N -oxides with acetone was developed. Abstract : A highly enantioselective formal [3 + 3] annulation of 2-enoyl-pyridine N -oxides with acetone was developed. In this transformation, an amino-acid saltl -phenylalanine potassium proved to be a robust organocatalyst, and the corresponding annulation derivatives can be obtained with moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 94%).