Alteration of thiol-disulfide homeostasis in workers occupationally exposed to arsenic. Issue 2 (4th March 2018)

• Record Type: Journal Article
• Authors: Büyükşekerci, Murat; Bal, Ceylan; Serkant, Utku; Gündüzöz, Meşide; Alışık, Murat; Tutkun, Engin; Yılmaz, Ömer Hınç
• Is Part Of: Archives of environmental & occupational health. Volume 73:Issue 2(2018)
• Page Start: 90
• Page End: 95
• Publication Date: 2018-03-04
• Subjects: Arsenic exposure -- isoprostane -- oxidative stress -- thiol-disulfide homeostasis; Medicine, Preventive -- Periodicals; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational diseases -- Periodicals; Environmental Health -- Periodicals; Occupational Medicine -- Periodicals; 616.9803
• DOI: 10.1080/19338244.2017.1287047
• Languages: English
• ISSNs: 1933-8244

Abstract

ABSTRACT: This study evaluates the redox state in occupationally arsenic-exposed workers ( n = 71) by assessing the dynamic serum thiol-disulfide homeostasis. We determined the serum thiol-disulfide homeostasis parameters of exposed workers and controls ( n = 43) using a novel automated colorimetric assay. Median urinary As and 8-isoprostane levels of exposed group were significantly higher than control group (16.40 μg/L vs 2μg/L, p < .001 and 2.28 ng/ml vs 0.54 ng/ml, p < .001, respectively). Disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio were significantly higher in exposed group. The mean ceruloplasmine and myeloperoxidase activities of As-exposed group were significantly higher than control group (117.15 U/L vs 87.02 U/L, p = .035 and 148.53 U/L vs 97.75 U/L, p = .000, respectively). The median catalase activity did not differ in the two groups. Our findings revealed that As disrupts the thiol-disulfide homeostasis in favor of disulfide.