Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. (February 2018)

• Record Type: Journal Article
• Authors: Liu, Chung-Hsiang; Tsai, Chon-Haw; Huang, Wei-Shih; Lu, Chung-Ta; Tsai, Tzung-Chang; Tseng, Chun-Hung; Lin, Kang-Hsu; Shyu, Woei-Cherng; Yang, Yu-Wan; Liu, Yen-Liang; Cho, Der-Yang; Chen, Chun-Chung; Jeng, Jiann-Shing; Tang, Sung-Chun; Tsai, Li-Kai; Yeh, Shin-Joe; Chen, Chih-Hao; Tsai, Hsin-Hsi; Li, Jie-Yuan; Chen, Han-Jung; Lu, Kan; Hsu, Shih-Pin; Kuo, Hung-Chang; Tsou, Jung-Chi; Wang, Yan-Tang; Tai, Yi-Cheng; Hsieh, Meng-Tsang; Liliang, Po-Chao; Liang, Cheng-Loong; Wang, Hao-Kuang; Tsai, Yu-Tun; Wang, Kuo-Wei; Chen, Jui-Sheng; Chen, Po-Yuan; Wang, Yi-Ching; Chen, Chih-Hung; Sung, Pi-Shan; Hsieh, Han-Chieh; Su, Hui-Chen; Chiu, Hou-Chang; Lien, Li-Ming; Chen, Wei-Hung; Bai, Chyi-Huey; Huang, Tzu-Hsuan; Lau, Chi-Ieong; Wu, Ya-Ying; Yeh, Hsu-Ling; Chang, Anna; Lin, Ching-Huang; Yen, Cheng-Chang; Lin, Ruey-Tay; Chen, Chun-Hung; Khor, Gim-Thean; Chao, A-Ching; Lin, Hsiu-Fen; Huang, Poyin; Lin, Huey-Juan; Ke, Der-Shin; Chang, Chia-Yu; Yeh, Poh-Shiow; Lin, Kao-Chang; Cheng, Tain-Junn; Chou, Chih-Ho; Yang, Chun-Ming; Shen, Hsiu-Chu; Chen, An-Chih; Tsai, Shih-Jei; Lu, Tsong-Ming; Kung, Sheng-Ling; Lee, Mei-Ju; Chou, Hsi-Hsien; Chang, Wei-Lun; Chiu, Pai-Yi; Hsu, Min-Hsien; Chan, Po-Chi; Pan, Chau-Hsiung; Shoung, Hai-Ming; Lo, Yi-Chen; Wang, Fu-Hwa; Chang, Wei-Chieh; Lai, Ta-Chang; Yin, Jiu-Haw; Wang, Chung-Jen; Wang, Kai-Chen; Chen, Li-Mei; Denq, Jong-Chyou; Sun, Yu; Lu, Chien-Jung; Lin, Cheng-Huai; Huang, Chieh-Cheng; Liu, Chang-Hsiu; Chan, Hoi-Fong; Lee, Siu-Pak; Sun, Ming-Hui; Ke, Li-Ying; Chen, Po-Lin; Lee, Yu-Shan; Sung, Sheng-Feng; Ong, Cheung-Ter; Wu, Chi-Shun; Hsu, Yung-Chu; Su, Yu-Hsiang; Hung, Ling-Chien; Lee, Jiunn-Tay; Lin, Jiann-Chyun; Hsu, Yaw-Don; Denq, Jong-Chyou; Peng, Giia-Sheun; Hsu, Chang-Hung; Lin, Chun-Chieh; Yen, Che-Hung; Cheng, Chun-An; Sung, Yueh-Feng; Chen, Yuan-Liang; Lien, Ming-Tung; Chou, Chung-Hsing; Liu, Chia-Chen; Yang, Fu-Chi; Wu, Yi-Chung; Tso, An-Chen; Lai, Yu- Hua; Chiang, Chun-I.; Tsai, Chia-Kuang; Liu, Meng-Ta; Lin, Ying-Che; Hsu, Yu-Chuan; Chiang, Tsuey-Ru; Huang, Pai-Hao; Liao, Pin-Wen; Lee, Mei-Ching; Chen, Jen-Tse; Lie, Sian-King; Sun, Mu-Chien; Hsiao, Pi-Ju; Chen, Wei-Liang; Chen, Ta-Cheng; Chang, Chen-Shu; Lai, Chien-Hsu; Chuang, Chieh-Sen; Chen, Yen-Yu; Lin, Shinn-Kuang; Su, Yu-Chin; Shiao, Jen-Lun; Yang, Fu-Yi; Liu, Chih-Yang; Chiang, Han-Lin; Chen, Guei-Chiuan; Hsu, Po-Jen; Chang, Chun-Yuan; Lin, I.-sheng; Chien, Chung-Hsien; Chang, Yang-Chuang; Chen, Ping-Kun; Chiu, Pai-Yi; Hsiao, Yu-Jen; Fang, Chen-Wen; Chen, Yu-Wei; Lee, Kuo-Ying; Lin, Yun-Yu; Li, Chen-Hua; Tsai, Hui-Fen; Hsieh, Chuan-Fa; Yang, Chih-Dong; Liaw, Shiumn-Jen; Liao, How-Chin; Yeh, Shoou-Jeng; Wu, Ling-Li; Hsieh, Liang-Po; Lee, Yong-Hui; Chen, Chung-Wen; Hsu, Chih-Shan; Jhih, Ye-Jian; Zhuang, Hao-Yu; Pan, Yan-Hong; Shih, Shin-An; Chen, Chin-I.; Sung, Jia-Ying; Weng, Hsing-Yu; Teng, Hao-Wen; Lee, Jing-Er; Huang, Chih-Shan; Chao, Shu-Ping; Yuan, Rey-Yue; Sheu, Jau-Jiuan; Yu, Jia-Ming; Ho, Chun-Sum; Lin, Ting-Chun; Yu, Shih-Chieh; Chen, Jiunn-Rong; Tsai, Song-Yen; Wei, Cheng-Yu; Hung, Chao-Hsien; Lee, Chia Fang; Yang, Sheng-Kung; Chen, Chih-Lin; Lin, Wei; Tseng, Hung-Pin; Liu, Chin-Hsiung; Lin, Chun-Liang; Lin, Hung-Chih; Chen, Pi-Tzu; Hu, Chaur-Jong; Chan, Lung; Chi, Nai-Fang; Chern, Chang-Ming; Lin, Chun-Jen; Wang, Shuu-Jiun; Hsu, Li-Chi; Wong, Wen-Jang; Lee, I-Hui; Yen, Der-Jen; Tsai, Ching-Piao; Kwan, Shang-Yeong; Soong, Bing-Wen; Chen, Shih-Pin; Liao, Kwong-Kum; Lin, Kung-Ping; Chen, Chien; Shan, Din-E.; Fuh, Jong-Ling; Wang, Pei-Ning; Lee, Yi-Chung; Yu, Yu-Hsiang; Huang, Hui-Chi; Tsai, Jui-Yao; Wu, Ming-Hsiu; Chiang, Szu-Yi; Wang, Chiung-Yao; Hsu, Ming-Chin; Chen, Chien-Chung; Yeh, Po-Yen; Tsai, Yu-Tai; Wang, Ko-Yi; Chen, Tsang-Shan; Hsieh, Cheng-Yang; Chen, Wei-Fen; Yip, Ping-Keung; Wang, Vinchi; Wang, Kaw-Chen; Tsai, Chung-Fen; Chen, Chao-Ching; Chen, Chih-Hao; Liu, Yi-Chien; Chen, Shao-Yuan; Zhao, Zi-Hao; Wei, Zhi-Peng; Wu, Shey-Lin; Liu, Ching-Kuan; Lin, Ryh-Huei; Chu, Ching-Hua; Yan, Sui-Hing; Lin, Yi-Chun; Chen, Pei-Yun; Hsiao, Sheng-Huang; Yip, Bak-Sau; Tsai, Pei-Chun; Chou, Ping-Chen; Kuo, Tsam-Ming; Lee, Yi-Chen; Chiu, Yi-Pin; Tsai, Kun-Chang; Liao, Yi-Sheng; Tsai, Ming-Jun; Kao, Hsin-Yi; Wang, I-Kuan; Liu, Chung-Hsiang; Yen, Tzung-Hai; Jeng, Jiann-Shing; Sung, Sheng-Feng; Huang, Pai-Hao; Li, Jie-Yuan; Sun, Yu; Wei, Cheng-Yu; Lien, Li-Ming; Tsai, I-Ju; Sung, Fung-Chang; Hsu, Chung Y.;
• Is Part Of: Atherosclerosis. Volume 269(2018)
• Page Start: 288
• Page End: 293
• Publication Date: 2018-02
• Subjects: Estimated glomerular filtration rate -- Ischemic stroke -- Mortality -- Renal function; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2017.11.029
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m 2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52, 732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m 2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m 2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m 2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m 2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m 2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m 2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m 2 . Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship. Highlights: This study aims to evaluate the short-term (1-month) and long-term (1-year) mortality for patients with acute ischemic stroke by the glomerular filtration rate (eGFR) levels measured at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m 2 or on dialysis. Patients with reduced eGFR were at higher risk of dying either at short- or long-term in a graded relationship.