Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients. (February 2018) - Yamamoto, Hiroyuki
Abstract: Background and aims: This study examined the impact of CD14 ++ CD16 + monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14 ++ CD16 + monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. Methods: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT. Patients were divided into 3 tertiles according to the CD14 ++ CD16 + monocyte percentages assessed by flow cytometry. Standard OCT parameters were assessed for 97 angiographically intermediate lesions (diameter stenosis: 30–70%). Daily glucose fluctuation was analyzed by measuring the mean amplitude of glycemic excursion (MAGE). Results: CD14 ++ CD16 + monocytes negatively correlated with fibrous cap thickness (r = −0.508, p < 0.01). The presence of thin-cap fibroatheroma (TCFA) was increased stepwise according to the tertile of CD14 ++ CD16 + monocytes (0 [tertile 1] vs. 5 [tertile 2] vs. 10 [tertile 3], p < 0.01). CD14 ++ CD16 + monocytes were a significant determinant of TCFA (OR 1.279, p = 0.001). In non-DM patients, a significant relationship was found between CD14 ++ CD16 + monocytes and MAGE (r = 0.477, p = 0.018). Conclusions: CD14 ++ CD16 + monocytes were associated with coronary plaque vulnerability in CAD patients with well-regulated lipid levels both in DM and non-DM patients. Cross-talk between glucose fluctuation and CD14 ++ CD16 + monocytes may enhance plaque vulnerability, particularly in non-DM patients. CD14 ++ CD16 + monocytes could be a possible therapeutic target for coronary plaque stabilization. Highlights: Fibrous cap thickness was negatively correlated with CD14 ++ CD16 + monocyte levels. CD14 ++ CD16 + monocyte levels was an independent predictor for TCFA. MAGE scores were significantly higher in patients with TCFA than in those without. CD14 ++ CD16 + monocyte levels correlated with MAGE score in non-DM patients.