Aberrant frequency of IL-35 producing B cells in colorectal cancer patients. (February 2018)

• Record Type: Journal Article
• Authors: Wang, Ke; Gong, Hui; Chai, Rui; Yuan, Hang; Chen, Yanxia; Liu, Jinlin
• Is Part Of: Cytokine. Volume 102(2018)
• Page Start: 206
• Page End: 210
• Publication Date: 2018-02
• Subjects: CRC colorectal cancer -- Breg regulatory B cells -- Treg cells regulatory T cells -- MDSCs myeloid‑derived suppressor cells; Colorectal cancer -- IL-35 producing B cells; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2017.10.011
• Languages: English
• ISSNs: 1043-4666

Abstract

Abstract: Background: The IL-10 dependent regulatory function of B cells had recently more and more investigated and play important roles in cancer immunity, however, beyond IL-10 whether other inhibitory cytokines play an important role in cancer is lacking. Here, we investigated the role of IL-35 producing B cells in colorectal cancer (CRC). Methods: Thirty-two healthy controls (HC) and 49 untreated CRC patients were enrolled and the IL-35 producing B cells in the peripheral blood were investigated. Additionally, CD4 + CD25 +/high CD127 low/− regulatory T (Treg) and CD14 + HLA-DR low/− myeloid‑derived suppressor cells (MDSCs) were also investigated. Results: Results show that IL-35 producing B cells were significantly upregulated during the clinical progression of CRC, and negatively correlated with CD3 + T cell, positively correlated with the frequency of CD4 + CD25 +/high CD127 low/− Treg cells and CD14 + HLA-DR low/− MDSCs of these CRC patients. Conclusions: Together, IL-35 producing B cells were significantly elevated in CRC, indicating this B cell subset might participate in the immune suppression of CRC.