Exploration of adherence and patient experiences with DOACs one year after switching from vitamin-K antagonists- insights from the switching study. Issue 162 (February 2018)

• Record Type: Journal Article
• Authors: Bartoli- Abdou, John K.; Patel, Jignesh P.; Crawshaw, Jacob; Vadher, Bipin; Brown, Alison; Roberts, Lara N.; Patel, Raj K.; Arya, Roopen; Auyeung, Vivian
• Is Part Of: Thrombosis research. Issue 162(2018)
• Page Start: 62
• Page End: 68
• Publication Date: 2018-02
• Subjects: Warfarin -- Vitamin- K antagonists -- Direct oral anticoagulant -- DOAC -- Adherence -- Patient care -- Atrial fibrillation -- Venous thromboembolism -- Quality of life; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2017.12.021
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Background: Current UK and European guidelines recommend anticoagulated patients prescribed warfarin with time in therapeutic range (TTR) < 65% be considered for DOAC therapy. There has been considerable concern that adherence with DOACs may be poor compared with warfarin. Little is known about the patient experience of switching from warfarin to DOAC and how patients manage their DOAC long term. Our aim was to conduct focus groups exploring patient's previous experiences with warfarin, their current experience with DOACs, their adherence to DOACs and the long-term service provision they envisage. Methods: Patients enrolled on the Switching Study who had been switched from warfarin to a DOAC > 1 year previously were invited to participate in focus groups. Two focus groups for atrial fibrillation (AF) and two for secondary prevention of venous thromboembolism (VTE) patients were held at anticoagulation clinics in South London, UK. Data was analysed using framework analysis to extract dominant themes. Results: Five VTE patients and 15 AF patients attended the focus groups. Dominant themes that emerged were: indication specific anticoagulation prioritisation, warfarin as a necessary inconvenience, DOACs as the anticoagulant of choice, concerns regarding DOAC monitoring, high adherence to DOACs and desire for long-term access to specialist anticoagulation services. Discussion: VTE patients prioritised anticoagulation over other therapies whereas AF patients did not. All participants reported high levels of adherence to DOACs. Patients derived confidence from long-term management in specialist anticoagulation clinics stating a preference to be managed in such a service. Highlights: Patients value anticoagulation differently depending on indication for treatment Warfarin was valued highly by patients prior to DOAC switch. Patients prescribed DOACs report high levels of adherence after 1 year. Patients value long-term follow up with DOACs by specialists. AF and VTE expectations of DOAC monitoring differ widely.