IL-18 and Stem Cell Factor affect hematopoietic progenitor cells in HIV-infected patients treated during primary HIV infection. (March 2018)

• Record Type: Journal Article
• Authors: Bordoni, Veronica; Viola, Domenico; Sacchi, Alessandra; Pinnetti, Carmela; Casetti, Rita; Cimini, Eleonora; Tumino, Nicola; Antinori, Andrea; Ammassari, Adriana; Agrati, Chiara
• Is Part Of: Cytokine. Volume 103(2018)
• Page Start: 34
• Page End: 37
• Publication Date: 2018-03
• Subjects: Primary HIV infection -- Hematopoietic progenitor cells -- Cytokines -- Early treatment; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2017.12.033
• Languages: English
• ISSNs: 1043-4666

Abstract

Graphical abstract: Highlights: ART in primary HIV infection restores the decline of lymphoid progenitors. ART in primary HIV infection induces a decrease of IL-18 and an increase of SCF. Lymphoid progenitors frequency correlates with IL-18 and SCF before and after ART. SCF receptor expression on hematopoietic progenitors decreases after early ART. Abstract: The impact of early antiretroviral therapy (ART) during Primary HIV Infection (PHI) on the hematopoietic progenitor cells (HPCs) homeostasis is not available. This study aimed to characterize HPCs and their relationship with cytokines regulating progenitors function in ART-treated patients with PHI. We enrolled HIV infected patients treated with ART during PHI. Circulating HPCs, Lymphoid-HPCs (L-HPCs) frequency and plasmatic concentrations of IL-7, IL-18 and Stem Cell Factor (SCF) were analysed at baseline and after 6 months of therapy. ART introduction during PHI restored the decline of L-HPCs, induced a decrease in the level of pro-inflammatory IL-18 cytokine and a parallel increase of SCF. Moreover, L-HPCs frequency positively correlated with IL-18 at baseline, and with SCF after 6 months of therapy, suggesting that different signals impact L-HPCs expansion and maintenance before and after treatment. Finally, the SCF receptor expression on HPCs decreased after early ART initiation. These insights may open new perspectives for the evaluation of cytokine-driven L-HPCs expansion and their impact on the homeostasis of hematopoietic compartment during HIV infection.