Solid Supported Nano Structured Cu‐Catalyst for Solvent/Ligand Free C2 Amination of Azoles. Issue 5 (2nd February 2018)

• Record Type: Journal Article
• Authors: Dutta, Pratip Kumar; Sen, Subhabrata; Saha, Debasree; Dhar, Basabbijayi
• Is Part Of: European journal of organic chemistry. Issue 5(2018)
• Page Start: 657
• Page End: 665
• Publication Date: 2018-02-02
• Subjects: Synthetic methods -- Nitrogen heterocycles -- Supported catalysts -- Thiazole -- Nanoparticles; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201701669
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Ligand‐ and solvent‐free catalytic conditions that harness a nanostructured–Cu I catalyst encapsulated in TiO2 has been reported for C2‐amination of azoles (benzothiazole, benzoxazole and thiazole). The reaction is highly regioselective. The catalyst is robust, inexpensive and can be recycled up to four times. This strategy was further used for the synthesis of a small molecule with anti‐HIV and anti‐tumor properties. Abstract : A titanium oxide encapsulated recyclable cuprous iodide nanocatalyst that promotes amination of azoles is reported.