Investigation of metal–polyelectrolyte complex toxicity. (May 2014)

• Record Type: Journal Article
• Authors: Karahan, Mesut; Mustafaeva, Zeynep; Koç, Rabia Çakır; Bağırova, Melahat; Allahverdiyev, Adil M
• Is Part Of: Toxicology and industrial health. Volume 30:Number 4(2014:May)
• Page Start: 384
• Page End: 389
• Publication Date: 2014-05
• Subjects: Polymer-metal complexes -- transition metal chemistry -- polyelectrolyte -- proteins -- toxicity; Toxicology, Experimental -- Periodicals; Industrial toxicology -- Periodicals; 615.9
• DOI: 10.1177/0748233712457446
• Languages: English
• ISSNs: 0748-2337

Abstract

Water-soluble binary and ternary copper complexes of polyelectrolytes were synthesized, and the toxicity of these complexes was tested in mouse fibroblast cell line (L929) in vitro . Both the binary and ternary complexes were prepared at the ratio of 0.4 mole copper(II) ions per monomer of acrylic acid and 0.5 mole copper(II) ions per monomer of methyl vinyl ether maleic anhydride, furthermore at the ratio of 1 and 2 mole bovine serum albumin per mole of polyacrylic acid and poly(methyl vinyl ether-co-maleic anhydride), respectively. Compared to binary copper(II)–polyelectrolyte complexes, these ternary complexes have been determined to be of least toxicity.