Early impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis—Burkina Faso, 2014–2015. Issue 3 (March 2018)

• Record Type: Journal Article
• Authors: Kambiré, Dinanibè; Soeters, Heidi M.; Ouédraogo-Traoré, Rasmata; Medah, Isaïe; Sangaré, Lassana; Yaméogo, Issaka; Sawadogo, Guetawendé; Ouédraogo, Abdoul-Salam; Ouangraoua, Soumeya; McGee, Lesley; Srinivasan, Velusamy; Aké, Flavien; Congo-Ouédraogo, Malika; Ky Ba, Absatou; Whitney, Cynthia G.; Novak, Ryan T.; Van Beneden, Chris
• Is Part Of: Journal of infection. Volume 76:Issue 3(2018)
• Page Start: 270
• Page End: 279
• Publication Date: 2018-03
• Subjects: Pneumococcal conjugate vaccine -- Meningitis -- Pneumococcal meningitis -- Surveillance -- Vaccine impact -- Burkina Faso; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2017.12.002
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: Burkina Faso introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2013. By 2015, incidence of PCV13 pneumococcal meningitis decreased by 32%. Large decreases occurred among children aged <1 year (76%) and 1–4 years (58%). Abstract: Objectives: We evaluate early impact of 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in Burkina Faso. Methods: Nationwide surveillance gathered demographic/clinical information and cerebrospinal fluid (CSF) results for meningitis cases. Pneumococcal cases were confirmed by culture, polymerase chain reaction (PCR), or latex agglutination, and strains serotyped using PCR. We compared incidence (cases per 100, 000) in the early post-PCV13 period (2014 and 2015) to average pre-PCV13 incidence (2011–2013). Results: In 2015, age-specific pneumococcal meningitis incidences were 8.7 (<1 year), 2.4 (1–4 years), 6.5 (5–14 years), and 2.6 (≥15 years). Compared to 2011–2013, PCV13-serotype incidence among all ages decreased by 32% (95%CI: 23%–39%), with significant decreases among children aged <1 year (76%; 95%CI: 64%–84%) and 1–4 years (58%, 95%CI: 40%–71%). Among all ages, incidence of PCV13 serotypes besides serotype 1 decreased (68%; 95%CI: 59%–75%), but serotype 1 incidence did not. Incidence of non-PCV13 serotypes also decreased (47%; 95%CI: 29%–60%). Among children aged <1 year, serotypes 12F/12A/12B/44/46 (17%), 1 (12%), and 5 (10%) predominated. Conclusions: Following PCV13 introduction, PCV13-serotype meningitis incidence in young children significantly decreased. PCV13 impact on serotype 1 and disease in older children and adults requires continued monitoring.