PIM activity in tumours: A key node of therapy resistance. (January 2018)

• Record Type: Journal Article
• Authors: Rebello, Richard J.; Huglo, Alisée V.; Furic, Luc
• Is Part Of: Advances in biological regulation. Volume 67(2018)
• Page Start: 163
• Page End: 169
• Publication Date: 2018-01
• Subjects: Prostate -- Breast -- Cancer -- PIM -- MYC -- AKT -- mTOR -- mRNA translation; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2017.10.010
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.