Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells—Power of nutraceuticals. (January 2018)

• Record Type: Journal Article
• Authors: McCubrey, James A.; Abrams, Stephen L.; Lertpiriyapong, Kvin; Cocco, Lucio; Ratti, Stefano; Martelli, Alberto M.; Candido, Saverio; Libra, Massimo; Murata, Ramiro M.; Rosalen, Pedro L.; Lombardi, Paolo; Montalto, Giuseppe; Cervello, Melchiorre; Gizak, Agnieszka; Rakus, Dariusz; Steelman, Linda S.
• Is Part Of: Advances in biological regulation. Volume 67(2018)
• Page Start: 190
• Page End: 211
• Publication Date: 2018-01
• Subjects: Berberine -- Curcumin -- Resveratrol -- Metformin; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2017.09.012
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are consumed often by different cultures in various parts of the world, has become apparent. These "healthy" components of our diet are often referred to as nutraceuticals and they can prevent/suppress: aging, bacterial, fungal and viral infections, diabetes, inflammation, metabolic disorders and cardiovascular diseases and have other health-enhancing effects. Moreover, they are now often being investigated because of their anti-cancer properties/potentials. Understanding the effects of various natural products on cancer cells may enhance their usage as anti-proliferative agents which may be beneficial for many health problems. In this manuscript, we discuss and demonstrate how certain nutraceuticals may enhance other anti-cancer drugs to suppress proliferation of cancer cells.