Diversity‐Oriented Synthesis of Furo[3, 2‐c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction. (5th January 2018)

• Record Type: Journal Article
• Authors: Yang, Shu‐Mei; Wang, Chein‐Yi; Lin, Chun‐Kai; Karanam, Praneeth; Reddy, Ganapuram Madhusudhan; Tsai, Yi‐Ling; Lin, Wenwei
• Is Part Of: Angewandte Chemie. Volume 130:Number 6(2018)
• Page Start: 1684
• Page End: 1688
• Publication Date: 2018-01-05
• Subjects: Chemoselektivität -- Diversitätsorientierte Synthese -- Mehrkomponentenreaktionen -- Organophosphoniumsalze -- Wittig-Reaktion; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201711524
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A highly efficient and chemoselective one‐pot protocol for the diversity‐oriented synthesis of two types of coumarin‐based formal cross‐coupling adducts, furo[3, 2‐c]coumarins and 3‐benzofuranyl chromenones, is described. Key attributes of the methodology are an initial chemoselective acylation of functionalized phosphorus zwitterions and a subsequent chemoselective intramolecular Wittig reaction that preferentially resulted in one of the two coumarin derivatives in high yield, depending on relative reactivities and the addition sequence of the acylating agents.