Acid/Base‐Co‐catalyzed Direct Oxidative α‐Amination of Cyclic Ketones: Using Molecular Oxygen as the Oxidant. Issue 3 (28th November 2017)

• Record Type: Journal Article
• Authors: Li, Yi‐Jin; Zhang, Lu; Yan, Na; Meng, Xiang‐He; Zhao, Yu‐Long
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 3(2018)
• Page Start: 455
• Page End: 461
• Publication Date: 2017-11-28
• Subjects: aerobic oxidation -- cyclic ketones -- α-amination -- organocatalysis -- dehydrogenation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201701103
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A novel acid/base‐co‐catalyzed direct intermolecular α‐amination of various cyclic ketones has been developed for the first time. The reaction employs molecular oxygen as the sole oxidant under metal‐free conditions. The reaction tolerates a wide range of various anilines, especially primary diamine derivatives, and provides a simple and efficient method for the constructions of α‐amino enones and benzodiazepine derivatives in a single step. Abstract :