Cover Picture: Intracellular Delivery of Native Proteins Facilitated by Cell‐Penetrating Poly(disulfide)s (Angew. Chem. Int. Ed. 6/2018). Issue 6 (11th January 2018)

• Record Type: Journal Article
• Authors: Qian, Linghui; Fu, Jiaqi; Yuan, Peiyan; Du, Shubo; Huang, Wei; Li, Lin; Yao, Shao Q.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 6(2018)
• Page Start: 1421
• Page End: 1421
• Publication Date: 2018-01-11
• Subjects: antibodies -- bioorthogonal chemistry -- cell-penetrating poly(disulfide)s -- intracellular delivery -- native proteins; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201800062
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Intracellular Transport A method for the delivery of native proteins into the cytosol of live mammalian cells with immediate bioavailability is described by L. Li, S. Q. Yao et al. in their Communication onpage 1532. They report novel conjugation chemistries capable of covalent modification of native proteins with cell‐penetrating poly(disulfide)s (CPDs). The picture shows a classical Chinese painting, with the boat representing CPDs providing the passengers (proteins) speedy travel to the intended destination (cell).