Metal‐Free Catalyst‐Controlled Chemoselective Synthesis of Aryl α‐Ketoesters and Primary α‐Ketoamides from Aryl Acetimidates. Issue 21 (28th July 2017)

• Record Type: Journal Article
• Authors: Kumar, Yogesh; Jaiswal, Yogesh; Shaw, Mukta; Kumar, Amit
• Is Part Of: ChemistrySelect. Volume 2:Issue 21(2017)
• Page Start: 6143
• Page End: 6148
• Publication Date: 2017-07-28
• Subjects: Arylacetimidates -- Aryl α-ketoesters -- Chemoselective -- Metal-free catalyst -- Primary α-ketoamides; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701322
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A simple and chemoselective method has been developed for the divergent synthesis of aryl α ‐ketoesters and primary α ‐ketoamides from pre‐functionalized arylacetimidates under metal‐free conditions. The chemoselective outcome is controlled by the subtle catalyst. This methodology features operational simplicity with broad substrate scope, metal‐free catalyst, and usage of easy to handle reagents. Based on a series of control experiments, a plausible reaction mechanism is also proposed. Abstract : A simple and chemoselective method has been developed for the divergent synthesis of aryl α ‐ketoesters and primary α ‐ketoamides from pre‐functionalized arylacetimidates under metal‐free conditions. The chemoselective outcome is controlled by the subtle catalyst. This methodology features operational simplicity with broad substrate scope, metal‐free catalyst, and usage of easy to handle reagents.