A domain-based DNA circuit for smart single-nucleotide variant identification. Issue 11 (27th November 2017)

• Record Type: Journal Article
• Authors: Zhong, Weiye; Tang, Weiyang; Fan, Jin; Zhang, Junmin; Zhou, Xuechang; Liu, Yizhen
• Is Part Of: Chemical communications. Volume 54:Issue 11(2018)
• Page Start: 1311
• Page End: 1314
• Publication Date: 2017-11-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc07733e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : By constructing a domain-based 4-to-2 encoder, we have realized the smart identification of SNVs from four homologous strands with one test instead of four, greatly enhancing the identification efficiency. Abstract : According to the differential information of four homologous oligonucleotides, two domain-based encoders have been constructed with the molecular information as the input. Based on the one-to-one correspondence between the input and output, SNVs can be identified and their sites can be located at the domain level.