Effect of the aqueous extract of Senecio biafrae (Oliv. & Hiern) J. Moore on some fertility parameters in immature female rat. (23rd February 2015)

• Record Type: Journal Article
• Authors: Lienou, L.L.; Telefo, P.B.; Njimou, J.R.; Nangue, C.; Bayala, B.R.; Goka, S.C.; Biapa, P.; Yemele, M.D.; Donfack, N.J.; Mbemya, J.T.; Tagne, S.R.; Rodrigues, A.P.R.
• Is Part Of: Journal of ethnopharmacology. Volume 161(2015)
• Page Start: 156
• Page End: 162
• Publication Date: 2015-02-23
• Subjects: Apigenin CID 5280443 -- Quercetin CID 5280343 -- Eugenol CID 3314 -- Theobromine CID 5429 -- Caffeic acid CID 689043 -- Hydroxy-tyrosol CID 216200 -- Catechin CID 9064 -- Rutin CID 5280805 -- Phenol CID 996; Aqueous extract -- Senecio biafrae -- Fertility -- Ovary -- Uterus; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2014.12.014
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Senecio biafrae is a plant from the huge family of Asteraceae used in the African pharmacopoeia for the treatment of many ailments among which is infertility. Material and methods: The aqueous extract, which was primarily subjected to polyphenol analysis, has been administered to immature female rats for 20 days at 8, 32, 64 and 128 mg/kg of body weight. The day following the treatment, the animals were sacrificed; their serum, ovary and uterus were retained respectively for reproductive hormones, ovarian and uterine proteins, and ovarian cholesterol assays. Results: Light body weight gain variation of treated animals was observed during the experimental period. A significant increase ( p ˂0.05) in serum estradiol and proteins as well as in uterine weight ( p ˂0.01) of all Senecio biafrae treated animals was noted. No significant variation was noticed in the ovarian weight and follicle numbers. Conclusion: The various biochemical and physiological parameters of fertility were significantly improved with the aqueous extract of Senecio biafrae, thus attesting some of its traditional usage. Graphical abstract: